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176,210,211 These effects involve interactions with other satiety and hunger signals, such as PYY, CCK, insulin, and leptin

Pharmacokinetic studies in rodents have documented rapid absorption following subcutaneous injection (Tmax approximately 30 minutes), with distribution to multiple tissues including liver, kidney, skin, and lung

Several studies showed evident association between type II diabetes and cancer, in particular in liver and pancreas, organs persistently exposed to high levels of endogenous insulin 117,118,119

For the PD model, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the substantia nigra were used to replicate PD pathology