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For the full Phase 3 safety profile, see our complete retatrutide side effects guide

The FDA People with EPP experience severe pain and other skin reactions when exposing their skin to any type of light

Nishimura EK, et al

Contact your GP, trial team, or seek urgent medical care if you experience any of the following: Diarrhoea lasting more than seven days without improvement Blood or mucus in the stool, which may indicate colitis or another serious gastrointestinal condition Signs of dehydration, including dizziness, reduced urine output, dry mouth, or confusion particularly in older adults or those with diabetes

Some people also notice increased burping, mild heartburn, or a feeling of fullness that arrives earlier than usual during meals