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In addition to a significant reduction in senescent cell burden within tissues treated with FOXO4-DRI, restoration of functional integrity was observed in organs such as the kidneys, liver, and skin

The microchannels created by needling allow the peptide to bypass the skin barrier and penetrate directly into the dermis dramatically increasing absorption compared to surface application alone

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This setup gives researchers a practical way to study angiogenic upregulation, cytoskeletal dynamics, and extracellular matrix (ECM) remodelling all at once, rather than running separate isolated assays

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