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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

Expert Review of Endocrinology & Metabolism, 2025) The Fertility Paradox Worth Discussing With Your Provider For patients not actively trying to conceive, restored ovulation can be an unexpected and clinically significant side effect of treatment meaning contraception planning should be part of the conversation when starting GLP-1 therapy for PCOS, not an afterthought

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Tough stuff, right