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Key mechanisms include: Activation of neurons in the area postrema and nucleus tractus solitarius in the brainstem Enhanced satiety signaling through distinct pathways from GLP-1 mechanisms Slowed gastric emptying via calcitonin receptor-mediated effects Reduced food reward signaling and decreased food noise through central appetite centers Studies in knockout mouse models confirmed that cagrilintides weight loss effects depend specifically on AMY1R and AMY3R presence, demonstrating receptor-specific mechanisms

Coverage at NY Times, front page today and my input to that piece To view or add a comment, sign in Pseudoscience So heres the whole story on why the FDA is endorsing peptides where there is a lack of solid scientific evidence that they have any effect eg on inflammation, weight loss, longeivity Essentially they added 6 people to the decision making committee who had a specific interests in supporting the sale of these peptides

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide with the amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val