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For example, in MC3T3-E1 cells cultured in high glucose, NAC inhibits the PI3K/AKT pathway (Liu and Yang, 2016), while in dexamethasone-stimulated MC3T3-E1 cells and human DFSCs cultured under standard conditions, it activates PI3K signaling (Deng et al., 2019
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Gradual titration helps minimize these effects
Phase 2 detoxification is the critical step where these highly reactive intermediates are neutralized and prepared for safe excretion from the body
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