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Tirzepatide (Mounjaro and Zepbound) The tirzepatide label uses nearly identical language
Peptides 86 , 15 (2016)
They use derivatives of different adenoviruses as vectors for reasons more specifically discussed in section Distinguishing features of vaccines independent of immunogen, as follows: CanSinohuman adenovirus 5 61 , Janssen-Johnson&Johnsonhuman adenovirus 26 19,62,63 , Oxford-AstraZenecachimpanzee adenovirus Y25 64,65,66
This modification is shared with tirzepatide and other modern incretin analogs, and is essential for achieving the extended duration of action required for once-weekly dosing
However, its mechanism of action needs to be further studied (Zhao et al., 2011)
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