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It suppresses appetite and it tells your body to increase energy expenditure to actively burn stored fat, particularly in the liver

Lack of sleep: When you don't get enough sleep, your body produces more ghrelin and less leptin, leading to increased appetite and cravings, especially for high-calorie, high-carb foods Chronic stress: Stress increases the hormone cortisol, which can also drive up appetite and lead to cravings for "comfort food." High cortisol levels can also disrupt your sleep, leading to more food cravings Even with semaglutide working in the background, a sleepless night or a stressful week can create hormonal shifts that are powerful enough to make you feel hungry

Additionally, these medications stabilize blood sugar levels and may improve cholesterol profiles

In someone with already compromised kidney function, that fluid loss can push them into acute kidney injury

Fleming MS, Ramos D, Han SB, Zhao J, Son YJ, Luo W