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When you lack B12, your red blood cells become malformed, and the oxygen delivery is compromised, making you feel tired

doi:10.2337/db23-0377

MT-I vs MT-II: Melanotan I (afamelanotide) is more selective for MC1R, so it delivers the tanning effect with far less of the appetite-suppression and spontaneous-erection activity that MT-II produces at MC3/MC4 receptors but it is generally used more frequently to reach the same pigmentation [2]

Retrieved 26 September 2018