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Sitagliptin blocks the DPP4 enzyme, preventing the breakdown of incretin hormones
The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
Like most medications, GLP-1s have potential side effects
2 The 28.7% figure is the largest average weight loss reported in any Phase 3 obesity trial so far
Even with significant appetite suppression reducing intake by 500 to 700 calories per day, actual fat loss accumulates at one to two pounds per week
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