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As a peptidomimetic rather than a true peptide, Dihexa resists gastrointestinal peptidase degradation and crosses the intestinal epithelium

Future research should prioritize high-quality trials to evaluate mitochondrial-targeted interventions, validate redox-based biomarkers, and optimize treatment protocols for improved patient outcomes

We also found that clofazimine had no obvious effect on the activity of main protease and papain-like protease, which are responsible for the cleavage of viral polypeptide (half-maximal inhibitory concentration (IC 50 ) of over 100 M) (Extended Data Fig

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62