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In addition, consistent with the findings reported elsewhere, we found DMF induces the activation of NRF2, and NRF2 targets such as those involved in cystine uptake (SLC7A11) and GSH biosynthesis (GCLM and GCLC, the mediator and catalytic subunits of GCL) (Fig

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All participants gave written informed consent and this part of the study was approved by the local ethics committee of Ludwig-Maximilians University of Munich, Germany (333-10) and carried out in accordance with the approved guidelines