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Mounjaro was approved by the FDA in 2022 as a GIP and GLP-1 receptor agonist for improving blood sugar control in adults with type 2 diabetes, and subsequent trials went on to evaluate its effects specifically on body weight in people with obesity or overweight

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For example, one JAMA analysis found that among initially-rejected branded prescriptions (all drugs), only 54% were ultimately approved after appeals and resubmissions ( [5] )