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However, theres an important caveat: most of the data comes from animal research, not human clinical trials

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For instance, it has been shown that after an experimental psychologic stress, the evoked cortisol response in fatigued breast cancer survivors is much smaller than that in nonfatigued ones, pointing to the involvement of the HPA axis in cancer-related fatigue (286)

Conditions such as obesity, loss of muscle mass, osteoporosis, and many inflammatory conditions resulting from autoimmune conditions, fibromyalgia, and chronic fatigue could be improved by the use of certain peptides