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This transition will be driven by accumulating health economic evidence demonstrating cost-effectiveness through reduced cardiovascular events and progression of metabolic disease, leading to structured public reimbursement programs in Europe, Japan, and middle-income countries

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Ramos et al., 2024)

154 Therefore, for cancers with p53 aggregates, the development and exploration of molecules that can stabilize the folded structure, suppress aggregation, or disrupt the formation of aggregates are of considerable therapeutic interest

10.1517/14728220903018932 40 Kalo-KleinA.WitkinS