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In published preclinical work, inhibiting NNMT is associated with elevated intracellular NAD and SAM, reduced lipogenesis and smaller adipocytes in cell and diet-induced-obese rodent models, and is studied in the context of insulin sensitivity and muscle function

This direct route makes it incredibly effective, especially for anyone who struggles with absorbing B12 through their gut, such as those with pernicious anemia

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It activates VEGFR2 (vascular endothelial growth factor receptor 2), triggering the PI3K-Akt-eNOS cascade and elevating nitric oxide production

Are there risks to supplementing with Vitamin B6 or B12