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Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimers disease: a phase 1b, randomized, placebo-controlled trial
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It is a solid clinical trial that directly demonstrates for the first time in a well-controlled intervention study that semaglutide (a GLP-1 receptor agonist) reduces alcohol consumption in patients undergoing treatment for alcohol use disorder and obesity
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In the body-composition subgroup, total fat mass fell 19.3% while lean body mass fell 9.7%, and lean mass as a proportion of total body mass actually rose by 3.0 percentage points
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