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Active or recent malignancy is treated as a hard contraindication in the clinical literature, and a history of hormone-sensitive cancer warrants specialist input

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Knee Osteoarthritis Retatrutide is also being investigated as an adjunctive treatment for adults living with both obesity and knee osteoarthritis

Semaglutide has a 7-day half-life, and it takes approximately 5 weeks for 97% elimination

If you feel particularly sensitive to changes in blood sugar or digestive activity, a light meal with protein and complex carbohydrates before your shot can be helpful