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Quinones M, Al-Massadi OA, Gallego R et al (2015) Hypothalamic CaMKK mediates glucagon anorectic effect and its diet-induced resistance
An analysis of insurance claims for GLP-1 weight-loss therapy (in patients without diabetes) found only 29% were still on the medication at 1 year, and a mere 15% at 2 years (source)
Whats Coming Orforglipron, Lillys oral GLP-1 (non-peptide), is in late-phase trials
Artmed Nicassio L, Fracasso F, Sirago G, Musicco C, Picca A, Marzetti E, Calvani R, Cantatore P, Gadaleta MN, Pesce V (2017) Dietary supplementation with acetyl- l -carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats
Treatment Duration and Results : While both Zepbound and Semaglutide are GLP-1 medications, their mechanisms differ
