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NICE advises that metformin should not normally be started if estimated glomerular filtration rate (eGFR) is below 45 mL/min/1.73m unless the benefits are expected to outweigh the potential risks
The good news is that the SURMOUNT-5 trial found no statistically significant difference in GI side effect rates between the two medications at their respective therapeutic doses
The fill-finish CDMOs need cartridges, the cartridges need an active ingredient, and that active ingredient is a peptide that has to be synthesised from raw chemical pieces
doi: 10.1016/j.jff.2024.106158 31
Comparison with other glucose-lowering agents, comprising sulfonylurea, dipeptidyl peptidase 4 inhibitors (DPP4-I) and SGLT2i are summarized in Supplementary Material 5
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