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The Canadian Journal of Psychiatry 2012;57(1):512

Prolonged moderate-intensity exercise without and with L-carnitine supplementation in patients with MCAD deficiency

A deficiency in B12 has been linked to premature greying in some studies

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What we dont know yet Because retatrutide is still in trials, there are unanswered questions: Long-term safety How sustainable the weight loss is Effects across different populations (diabetes, sleep apnoea, menopause) Risks of muscle loss, under-nutrition, or micronutrient deficiencies if lifestyle support isnt in place For women over 40, muscle preservation is non-negotiable