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After electron transfer to its substrate via the dithiol-disulfide exchange reaction, a disulfide bond is formed between Cys32 and Cys35, which is reduced by TrxR and NADPH
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Two randomized controlled trials demonstrated reduced bone loss during weight loss with GLP-1 RA compared to placebo (51, 52)
Riboflavin (vitamin B2) and vitamin D are additional cofactors that may support glutathione recycling and endogenous antioxidant production
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