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However, they differed on the exposure time: 24 h [111] or 48 h [112]
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FDA regulatory context: As of May 2026, the FDA has proposed excluding compounded semaglutide and tirzepatide from the 503B Bulks List, with a public comment period closing June 29, 2026
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It notes that GLP-1 medications increase heart rate, and that athletes with existing cardiac conditions face amplified risk from that effect
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