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89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

mean 115.6140.6 vs 60.660.6

There is considerable evidence that GLP1-RA confer cardiovascular and renal protective effects in patients with and without diabetes12

We do not know whether the insulin-sensitizing effects of GLP-1/GIP agonism adequately counterbalance the insulin-desensitizing effects of GH elevation when both occur simultaneously

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