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LNP-mediated in vivo DNA delivery in the mouse liver Efficient delivery of donor DNA, along with Cas9 and gRNA, is crucial for successful in vivo HITI
In June 2024, for instance, Lilly published detailed results from its Phase II SYNERGY-NASH study, demonstrating that tirzepatide could potentially improve fibrosisliver scarringin patients with metabolic dysfunction-associated steatohepatitis (MASH)
Individuals with a BMI under 27 kg/m without weight-related health conditions, as clinical benefits in this group are less established
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