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For mild forms, the combination of topical corticosteroids and vitamin D analogues remains the fundamental first step

This action is working in conjunction with the brain as it influences appetite suppression and energy expenditure by interacting with neuronal circuits that regulate hunger and fullness (Zhang et al

NICE recommends considering this for people with a BMI 40 kg/m or 35 kg/m with comorbidities (with lower thresholds for people from certain ethnic groups), and for people with type 2 diabetes with a BMI between 30-34.9 kg/m

24 weeks or more) showing the most noticeable improvements