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Mohale DS, Tripathi AS, Wahane JB, Chandewar AV (2021) A pharmacological review on cyclooxygenase enzyme

and (3) metabolites synthesized de novo by the microbiota, such as lipopolysaccharide (LPS) (34)

The randomized evidence establishes continued 2.4 mg treatment versus withdrawal, not a specific lower-dose maintenance band. The 0.5 and 1.0 mg doses have direct efficacy and safety data when assigned as treatment, and small uncontrolled series support testing lower-dose or reduced-frequency maintenance in practice

Abdulghani AA, Sherr S, Shirin S, et al

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