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On the 12mg maintenance dose, participants lost an average of 28.7% of body weight versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)

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( Related : 5 Ways to Break a Weight Loss Plateau That Actually Work) Non-response Then there are patients who may not experience any meaningful weight loss despite consistent use

Challenges in Medication Adherence While the study couldnt pinpoint the precise reasons behind patients halting their medication usage, researchers hypothesized that the gastrointestinal side effects significantly influenced these decisions