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NG239 Evidence review G: monitoring for gastric cancer in people with vitamin B12 deficiency due to autoimmune gastritis
This is the basis for twice-daily dosing
These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia
For optimal stability and effectiveness, vials should be stored in a cool, dry place (see Section 2 for detailed storage information)
[25] Supplementation with vitamin B 12 during conditions of deficiency restores the intracellular level of cobalamin and maintains a sufficient level of the two active coenzymes: methylcobalamin and adenosylcobalamin
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