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Studies have shown that GLP-1R agonists not only promote insulin secretion and exert glucose-lowering effects but also effectively delay gastric emptying, reduce intestinal motility, activate neural pathways in the hypothalamus and appetite regulation areas, resulting in decreased appetite and reduced food intake, thus treating obesity

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Oral semaglutide has been tested in large clinical trials, including the OASIS 1 and Phase 3a studies