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In addition to its principal activity in islet cells, ghrelin inhibits gastric secretion and gastrointestinal motility, delays gastric emptying, increases satiety and decreases food intake in gastrointestinal tissues (Brubaker and Drucker, 2002)

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Moreover, the overexpression of COX-2 is often closely associated with chemotherapy resistance and immune escape processes in tumors, suggesting that COX-2 is an attractive therapeutic target in tumors (107)

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Users should rotate injection sites to limit the damage