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They tried a few tricks: DPP-4-resistant versions: tweaking the GLP-1 molecule so DPP-4 cant see where to cut it Fatty acid tails: causing the GLP-1 to latch onto albumin in your blood, hiding from DPP-4 Encapsulation: wrapping the molecule in protective coatings so it survives longer before being exposed to enzymes These hacks meant the drug could hang out in the bloodstream for hours, or even days, instead of minutes

In some instances, they may consider weight loss surgery, including gastric bypass, gastric sleeve, or adjustable gastric banding

It also helps keep weight in check by slowing digestion and telling your brain that youre getting full

That is the test-before-you-invest approach

All studies had at least two arms (study medication and placebo)