This guide walks through the latest clinical evidence, including the 2025 SURMOUNT-5 head-to-head trial, so you can have an informed conversation with your provider
Moreover, Rybelsus, an oral formulation of semaglutide, is currently being tested in 2 ongoing studies (ClinicalTrials.gov, numbers NCT05813249 and NCT03919929)
Initially approved for type 2 diabetes management, semaglutide has been repositioned and rebranded across three products: Ozempic (injectable, for diabetes), Rybelsus (oral tablet, for diabetes), and Wegovy (injectable, higher dose, for obesity)
In reality, up to 70% of patients stop GLP-1 treatment within a year most often due to: High cost (GLP-1s can cost $1,000+ per month without insurance) Loss of insurance coverage for weight loss treatment Side effects such as nausea, diarrhea, constipation, or fatigue A Misconceptions some patients stop once they lose initial weight, believing they no longer need the medication 2
What to expect When you receive injections of B12 in your doctors office, your doctor will have considered the amount of the vitamin that is appropriate for you