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Figure 5: Changes in tissue weight in lean mice and obese mice across the three different experimental treatment groups

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Intestine-specific overexpression of carboxylesterase 2c protects mice from diet-induced liver steatosis and obesity

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

[1] Adiposity and Microbiome Studies Paired with a low-fat diet, 5-amino-1-methylquinolinium was used to study whole-body adiposity and weight change in DIO mice, moving several measures toward age-matched lean controls within the study window