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As integral components of the NVU, perivascular astrocytes maintain BBB characteristics by contributing to basement membrane formation, regulating pericyte differentiation, and modulating EC functions by regulating the expression of TJs such as claudin-5, occludin, and ZO-1 [49, 51,52,53]
bioRxiv , 2021.2009.2028.462109 (2021)
For example, jaundice from hepatitis may come with fever, tiredness, and loss of appetite, while jaundice from gallstones may cause sharp pain in the abdomen
Without treatment, this leads to megaloblastic anaemia and potentially serious neurological complications
