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The October 2025 analysis published in the Journal of the Endocrine Society (abstract SUN-659, with full peer-reviewed article at PMC12544991) reported retatrutide at a mean absolute reduction of 16.34 kg and 23.77% body weight versus 11.82 kg and 16.79% for tirzepatide, an indirect advantage in retatrutides favour 20

Tirzepatide HypoSpray therapy uses a transdermal spray format that may align with a patients preference for a non-injection routine when a licensed provider determines it is appropriate

Tablets could encourage hesitant patients to reconsider 65.30% of people who had considered GLP-1 injections but decided against them said they would likely seek a prescription if treatment was available as a tablet

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The article's reasoning is that patent expiry alone does not open the market, because FDA review, manufacturing scale-up, and regulatory exclusivity extensions can add two to five years