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For the treatment of negative symptoms of schizophrenia, MTZ was combined with clozapine in an 8-week, double-blind, placebo-controlled experiment

Am Fam Physician 83 Langan RC, Goodbred AJ (2017) Vitamin B12 deficiency: recognition and management

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However, the optimal dosing strategy remains debated, with some studies suggesting that intermittent high-dose regimens may be less effective or potentially harmful compared to daily dosing

In brief, metabolites were identified based on the Progenesis QI online METLIN database, public databases, and Biomarker Technologys self-built database