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doi: 10.1016/j.heliyon.2020.e05672 112 BerthelotJ-MLiotF
The logic: maximise the dose of the well-tolerated agent (petrelintide) and add a moderate dose of the more efficacious but less tolerable agent (CT-388, a GLP-1/GIP agonist), targeting 20%+ weight loss with a dramatically cleaner safety profile than pushing GLP-1 monotherapy to maximum dose
Retrieved May 6, 2025, from Burick Center
[1] Why Glutathione Levels Decline With Aging Like many biological molecules, glutathione levels decrease as people get older
Applying a binomial GLM indicated a significant effect of estrogen level on nausea and vomiting rates (p=.002 for pre/post GLP1R agonist, and p=.004 for pre/post x estrogen range) To determine percent weight loss, weights were first cleaned according to Rodriguez et al., 2024
