Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage
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Peroxiredoxin (Prx) 3, a cysteine-dependent peroxidase enzyme, is also present in the mitochondria, whereas Prx5 can also be found in the cytosol, in peroxisomes, and in the nucleus [28]
Dosing errors and excessive doses More is not better with peptides
To introduce thiol and amine functionality onto the SBA-15 MSNs, MPS and then APTES were injected into the reaction mixture