Common causes of constipation The causes of constipation also fall into several categories: Primary or idiopathic: This type of constipation, where the cause is unknown and not a symptom of another disease, falls into three categories
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These disorders can be associated with insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, resulting in insufficient energy supply, altered synaptic plasticity, death of neuronal cells, as well as functional and structural damage to reward networks
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