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Smith-Lemli-Opitz syndrome (SLOS) is an autosomal disorder associated with cholesterol biosynthesis

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In this context, the exploration of ME/CFS pathogenesis has increasingly focused on the microbiome-gut-brain axis, revealing a complex interplay between intestinal dysbiosis and the multifaceted symptomatology of this debilitating condition [10]

The normalized levels are shown as averages between the datasets before and after gastric bypass (Figure 4), and in each of the analyzed datasets (Figure 5)

Secondary endpoints included changes from baseline in patient-reported outcomes related to body image, triglycerides, ratio of total cholesterol to HDL cholesterol, IGF-1 levels, and safety parameters