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Acute striatal necrosis can be divided into three stages [70].The first stage is cytotoxic edema in the basal ganglia, cerebral ischemia, and increased blood volume in the gray matter, which occurs within 24 h after motor deficits, and cranial MRI shows increased signal intensity on T2-weighted imaging of the shell nucleus and caudate nucleus [71], along with diffusion limitation [72]

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R2Y and Q2 indicated the models goodness of fit (Supplementary Figure 4C)

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To restore ionic and glutamate homeostasis requires an increase in mitochondrial ATP production in the pre-synaptic and post synaptic neurons as well as the astrocytes

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Acetazolamide, a proven IIH therapy, appears to affect vitamin A metabolism

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