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Have complex medical histories: Individuals with a history of medullary thyroid carcinoma, MEN 2 syndrome, pancreatitis, severe gastrointestinal disease, or who are pregnant or nursing should not use GLP-1 medications

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Using metabolomics combined with PLSR and multi - index comprehensive methods, five metabolites, namely paeonol, dl - arabinose, benzoic acid, xilingolide A and paeonolide C, were found to be the effective metabolites of SGD in the treatment of neuropathic pain (Schrder et al., 2013)