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L., & Lingvay, I
Equally important is barrier support
Months 6 to 12: Long-term users who have made consistent dietary and lifestyle changes alongside medication report continued body composition improvements and weight maintenance
Published Phase 2 data (NEJM, 2023) showed retatrutide achieving up to 24.2% body weight reduction over 48 weeks and significant hepatic fat reduction, supporting research into obesity, NAFLD/MASH, and insulin resistance models
They work by slowing gastric emptying, reducing appetite, and improving insulin sensitivity
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