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Although baseline and month-6 between-group differences were small, the magnitude of reduction over time was significantly greater in the semaglutide group ( p = 0.001), with a large effect size (d = 0.99) (Table 2)

however, the study suggests that children under 12 may also benefit from their use

Wegovy (semaglutide) is a prescription injection approved to help with weight loss and reduce the risk of serious cardiovascular issues

46 Upper gastrointestinal disease, renal impairment and hepatic impairment did not affect oral semaglutide pharmacokinetic profile

The study was approved by the human ethics committee of Zhongshan Hospital of Fudan University (Ethics protocol approval number: B2018-121(2) and B2024-243R) and the Ethics Committee Board at the School of Basic Medical Sciences, Fudan University (Ethics protocol approval number: 2021-C004)