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Clinical Effectiveness for Weight Loss: Novo Nordisks 7.2mg Trials Novo Nordisks phase 3b trial studied 1,407 people with obesity over 72 weeks to test the efficacy and safety of semaglutide at the 7.2mg weekly dose regimen

PMID 24836310

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These suggests that the neuroprotective effects of berberine may be related to an excitatory mechanism that promotes cell survival and antioxidant-related signaling pathways