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Month-one weight loss on a GLP-1 may be modest because doses are intentionally started low and titrated up over several weeks

Current PL inhibitors like orlistat are constrained by limited long-term effectiveness and safety, highlighting the necessity for developing more effective and safer options for managing obesity [32, 41]

The effect of glucagon-like peptide-1 (GLP-1) receptor agonists in persons with obesity and knee osteoarthritis in this population has not been well-established. To test the impact of a GLP-1 receptor weight loss medication on knee OA outcomes, Bliddal and colleagues conducted a double-blind, randomized, placebo-controlled trial at 61 sites across 11 countries

When clinicians tailor the plan to the patient rather than pushing a standard schedule, tolerability often improves