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If youre an adult with a BMI of at least 30 or a BMI of 27 or higher with a weight-related condition such as high blood pressure, semaglutide could be an excellent option

Flexible Dosing Taking your medication twice weekly instead of once allows for more consistent blood levels and may help reduce side effects while maintaining appetite suppression

Avoid shaking the vials during reconstitution

Possible strategies to improve hepatic insulin sensitivity The most obvious approaches to improving insulin sensitivity are diet changes and exercise that result in weight loss

The December 2025 phase 3 results confirmed retatrutides position