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Flavonoids, specifically naringenin and hesperidin, are able to inhibit the TGF- pathway, which is known to be a key regulator of fibroblast activation and collagen production

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Pushing through with a dose increase typically makes symptoms worse, not better, and can lead to treatment discontinuation, which defeats the entire purpose of the graduated approach

The next step is prospective studies and clinical trials comparing patients with pretransplant diabetes on GLP-1 receptor agonists or dual agents to patients just on insulin or with any other oral medications, Campana said.