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GIP consists of 42 amino acids and is synthesized and secreted by endocrine K cells located mainly in the proximal duodenum and jejunum

Recessive mutations in genes coding for enzymes of the kynurenine pathway namely kynureninase and 3-hydroxyanthranilic-acid 3,4-dioxygenase lead to combined vertebral, anal, cardiac, tracheo-esophageal, renal, and limb (VACTERL) congenital malformations (76)

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However, the clinical advancement of oridonin faced limitations [24, 25], stemming not only from its unclear molecular mechanisms but also due to hydrophobicity and deficient targeting capabilities [26,27,28,29]